Methotrax 10mg 10pcs

✔️ Uses of

• Rheumatoid Arthritis and Psoriasis

✔️ How does

Methotrax 10 is an immunosuppressant, decreasing immune system activity. In psoriasis, it slows rapid skin cell growth.

✔️ Side Effects of

Abdominal pain, Indigestion, Loss of appetite, Nausea, Vomiting, Tiredness, Mouth sore.

✔️ Quick Suggestions:

• Take weekly, same day; stay hydrated.
• Consume folic acid to reduce side effects.
• Effects may take weeks; continue as prescribed.
• Avoid alcohol; harmful during pregnancy.
• Harmful to an unborn baby; avoid pregnancy.

✔️ Indications:

Burkitt's lymphoma, Choriocarcinoma, Mycosis fungoides, Crohn's disease, Psoriasis, Osteosarcoma, Breast cancer, Acute lymphoblastic leukaemia, Rheumatoid arthritis.

✔️ Pharmacology:

Methotrax 10 mg inhibits dihydrofolic acid reductase, interfering with DNA synthesis, repair, and cellular replication. It impairs malignant growth in actively proliferating tissues, more sensitive in malignant cells.

✔️ Dosage & Administration:

Neoplastic Diseases-Choriocarcinoma and similar trophoblastic diseases:

• Orally or intramuscularly, 15 to 30 mg daily for a five-day course.
• Courses are repeated 3 to 5 times as required, with rest periods of one or more weeks.
• Prophylactic chemotherapy is recommended for hydatidiform mole.

Acute Lymphoblastic Leukemia:

• Induction dose: 3.3 mg/m2 with prednisone 60 mg/m2 daily for 4 to 6 weeks.
• Maintenance dose: Orally or IM administration 2 times a week (total weekly doses of 30 mg/m2).
• Alternate maintenance dose: 2.5 mg/kg IV every 14 days.

Lymphoma Burkitt's tumor:

• Stages I to II: 10 to 25 mg once a day for 4 to 8 days.
• Stage III: Concomitant with other antitumor agents.
• Duration of therapy: Several courses with 7 to 10-day rest periods.

Lymphosarcoma Stage III:

• 0.625 to 2.5 mg/kg daily as part of combination chemotherapy.

Mycosis fungicides:

• Early stage dosing: 5 to 50 mg once a week or 15 to 37.5 mg 2 times a week.

Breast Cancer:

• 40 mg/m2 intravenously on the 1st and 8th day every 4 weeks in combination with cyclophosphamide and fluorouracil for 6-12 cycles.

Head and Neck Cancer:

• 40 mg/m2 IV weekly until disease progression or unacceptable toxicity (3 weeks equals one cycle; the goal is to complete at least six cycles).

Adult Rheumatoid Arthritis:

• Single doses of 7.5 mg once per week, Maximum dose: 20 mg/week in adults.

Polyarticular-Course Juvenile Rheumatoid Arthritis:

• 10 mg/m2 once weekly.

Psoriasis:

• Single dose: 10 to 25 mg once per week, maximum dose: 30 mg/week.

Administration of Methotrax 10 mg:

• Should be taken on an empty stomach. Best taken on an empty stomach.
• May be taken with meals to reduce GI discomfort.
• Avoid taking milk-rich products.

✔️ Interaction

• NSAIDs: Avoid before or concomitantly with high doses of Methotrax 10 mg.
• Salicylates, Phenylbutazone, Phenytoin, Sulfonamides: Increased toxicity.
• Monitoring is advised with Penicillin, Theophylline, Probenecid, Azathioprine, Retinoids, and Sulfasalazine.
• Caution with Cisplatin; increased plasma levels of mercaptopurine.
• Interaction with Tetracycline, Chloramphenicol, Nonabsorbable Broad Spectrum Antibiotics, Vitamin preparations containing folic acid or its derivatives, Trimethoprim/Sulfamethoxazole.

✔️ Contraindications

• Alcoholism, alcoholic liver disease, or other chronic liver disease.
• Immunodeficiency syndromes.
• Pre-existing blood dyscrasias, bone marrow hypoplasia, leukopenia, thrombocytopenia, or significant anemia.
• Hypersensitivity to Methotrax 10 mg.
• Pregnant women with psoriasis or rheumatoid arthritis.
• Women of childbearing potential.
• Nursing mothers.
• Pregnancy should be avoided during and after therapy.

✔️ Pregnancy & Lactation

Pregnancy category X. Contraindicated in pregnant and nursing women.

✔️ Precautions & Warnings

• Methotrax 10 mg formulations and diluents with preservatives must not be used for intrathecal or high-dose therapy.
• Close monitoring for toxic effects is required.
• Reduce dosage or discontinue if adverse reactions occur.
• Caution with reinstitution of Methotrax 10 mg therapy.
• Evaluation for persistent liver function test abnormalities, and depression of serum albumin.
• Folate deficiency may increase Methotrax 10 mg toxicity.

✔️ Overdose Effects of Methotrax 10 mg:

Leucovorin is indicated to diminish the toxicity and counteract inadvertent overdosages. Administer promptly.

✔️ Storage Conditions

Store at a temperature not exceeding 30°C in a dry place. Protect from light & moisture.